Angel Sanctuary

This anime centers on Setsuna Mudo, a confused high school student who is in love with his 15-year-old sister Sara. He discovers that he is the reincarnation of Organic Angel Alexiel while dealing with his incestuous feelings. Alexiel led a revolt against her fellow angels after seeing them kill the Evils, a group of demons, after God vanished. Inorganic Angel Rosiel, her younger twin brother, was imprisoned inside the Earth by her following the uprising because she was emotionally unable to grant his request to be killed before he went insane and started doing harm. After being captured and labeled a fallen angel, Alexiel was punished by having her body frozen and having her soul perpetually reincarnate as a miserable human.